Quais são os efeitos a longo prazo de tomar carbidopa levodopa?
A levodopa é administrada em combinação com o medicamento carbidopa (Sinemet® e suas versões genéricas). Esta combinação de medicamentos é considerada o tratamento padrão para os sintomas da doença de Parkinson, como tremor, rigidez muscular e lentidão de movimentos. Um efeito colateral do uso prolongado de levodopa édiscinesia.
Efeitos colaterais — Os efeitos colaterais mais comuns da levodopa sãonáusea, sonolência, tontura e dor de cabeça. Efeitos colaterais mais graves podem incluir confusão, alucinações, delírios, agitação e psicose; estes são mais comuns em pessoas mais velhas.
Além das flutuações, o uso prolongado de levodopa também é complicado pelo aparecimento de movimentos involuntários anormais, chamadosdiscinesias e distonias. As discinesias podem ser coreiformes (movimentos espasmódicos breves, geralmente afetando os membros) ou atetóides (movimentos de torção afetando os membros, face ou tronco).
Os sintomas de overdose podem incluir:tonturas graves, batimentos cardíacos irregulares, alterações mentais/de humor (como agitação). Não compartilhe este medicamento com outras pessoas. Exames laboratoriais e/ou médicos (como função cardíaca/renal/hepática, hemograma completo) devem ser realizados enquanto você estiver tomando este medicamento.
Os efeitos colaterais comuns da levodopa incluem:
Vômito.Perda de apetite.tontura.Pressão arterial reduzida.
Como a proteína pode interferir na resposta do corpo à carbidopa e à levodopa,dietas ricas em proteínasDeveria ser evitado. A ingestão de quantidades normais de proteína deve ser espaçada igualmente ao longo do dia ou conforme indicado pelo seu médico.
Os efeitos adversos comuns do tratamento com levodopa sãonáusea, tontura, dor de cabeça e sonolência. O aumento da carbidopa é recomendado para aliviar a náusea, e a domperidona pode ser útil se a carbidopa adicional for ineficaz.
Mesmo que comece a sentir-se melhor, é importante que continue a tomar carbidopa-levodopa. Se parar abruptamente de tomar o medicamento, corre o risco de complicações graves, incluindo uma condição potencialmente fatal conhecida como síndrome neuroléptica maligna.
“Embora a levodopa seja eficaz nos estágios iniciais da doença,à medida que a condição progride e surgem os sintomas de disfunção postural e da marcha, a droga torna-se ineficaz.” Em casos raros, a levodopa pode até exacerbar esses sintomas e causar piora da função cognitiva do paciente.
O efeito colateral mais grave da levodopa em pacientes éarritmia ventricular que é improvável de ocorrer em um indivíduo com coração normal, mas um risco em pacientes com irritabilidade miocárdica ou isquemia.
Qual é o máximo de carbidopa-levodopa por dia?
Adultos – Inicialmente, 25 miligramas (mg) de carbidopa e 100 mg de levodopa (1 comprimido) 3 vezes ao dia. O seu médico pode ajustar a sua dose conforme necessário e tolerado. No entanto, a dose geralmente não é superior a8 comprimidos inteiros por dia.
Tente tomar seu medicamento pelo menos 30 minutos antes de comer e lave-o com um copo grande de água (pelo menos 10 onças). Como a carbidopa-levodopa não é absorvida no estômago, mas sim no intestino delgado, beber água ajuda a mover o medicamento rapidamente para o intestino delgado.
Acredita-se que a dose diária mínima de carbidopa seja de 75 mg por dia. As informações sobre medicamentos aprovados pela FDA indicam que a dose diária de carbidopa não deve exceder200 mgporque não há experiência adequada com doses mais altas. Quais são os efeitos de doses de carbidopa acima das recomendadas?
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